St. James is a very small city located in the state of Missouri. With a population of 3,903 people and two associated neighborhoods, St. James is the 175th largest community in Missouri.

A relatively large number of people in St. James telecommute to their jobs. Overall, about 8.51% of the workforce works from home. While this may seem like a small number, as a fraction of the total workforce it ranks among the highest in the country. These workers are often telecommuters who work in knowledge-based, white-collar professions. For example, Silicon Valley has large numbers of people who telecommute. Other at-home workers may be self-employed people who operate small businesses out of their homes.

Being a small city, St. James does not have a public transit system used by locals to get to and from work.

The percentage of adults in St. James who are college-educated is close to the national average for all communities of 21.84%: 18.56% of the adults in St. James have a bachelor's degree or advanced degree.

The per capita income in St. James in 2022 was $23,711, which is lower middle income relative to Missouri, and low income relative to the rest of the US. This equates to an annual income of $94,844 for a family of four. However, St. James contains both very wealthy and poor people as well.

The people who call St. James home describe themselves as belonging to a variety of racial and ethnic groups. The greatest number of St. James residents report their race to be White, followed by Asian. Important ancestries of people in St. James include Irish, German, English, French, and Italian.

The most common language spoken in St. James is English. Other important languages spoken here include Italian and Chinese.