San Luis is a medium-sized city located in the state of Arizona. With a population of 35,770 people and six associated neighborhoods, San Luis is the 30th largest community in Arizona. Much of the housing stock in San Luis was built relatively recently. The construction of new real estate can often be taken as an indication that the local San Luis economy is robust, and that jobs or other amenities are attracting an influx of new residents. This seems to be the case in San Luis, where the median household income is $46,747.00.

The citizens of San Luis have a very low rate of college education: just 8.78% of people over 25 have a bachelor's degree or advanced degree, compared to a national average of 21.84% for all cities.

The per capita income in San Luis in 2018 was $16,690, which is low income relative to Arizona and the nation. This equates to an annual income of $66,760 for a family of four. However, San Luis contains both very wealthy and poor people as well.

San Luis is an extremely ethnically-diverse city. The people who call San Luis home describe themselves as belonging to a variety of racial and ethnic groups. People of Hispanic or Latino origin are the most prevalent group in San Luis, accounting for 94.21% of the city’s residents (people of Hispanic or Latino origin can be of any race). The greatest number of San Luis residents report their race to be White, followed by Black or African-American. Important ancestries of people in San Luis include German, European, Irish, Italian, and English.

Foreign born people are also an important part of San Luis's cultural character, accounting for 45.09% of the city’s population.

The most common language spoken in San Luis is Spanish. Other important languages spoken here include English and Italian.